A hPMS2 mutant cell line is defective in strand-specific mismatch repair.

@article{Risinger1995AHM,
  title={A hPMS2 mutant cell line is defective in strand-specific mismatch repair.},
  author={John Ian Risinger and Asad Umar and Jeffrey C. Barrett and T. A. Kunkel},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 31},
  pages={18183-6}
}
Human cells contain several homologs of the bacterial mutL gene required for mismatch repair, including a gene on chromosome 7 designated hPMS2. We have identified an endometrial carcinoma cell line, HEC-1-A, that has a C-->T mutation in hPMS2 that generates a nonsense codon and yields a protein truncated at the C terminus. No wild-type gene or gene product was detected. The missing amino acids in hPMS2 are highly conserved among PMS homologs, suggesting that they may be critical for function… CONTINUE READING