A gut-vascular barrier controls the systemic dissemination of bacteria

  title={A gut-vascular barrier controls the systemic dissemination of bacteria},
  author={Ilaria Spadoni and Elena Zagato and Alice Bertocchi and Roberta Paolinelli and Edina Hot and Antonio di Sabatino and Flavio Andrea Caprioli and Luca Bottiglieri and Amanda Oldani and Giuseppe Viale and Giuseppe Penna and Elisabetta Dejana and Maria Rescigno},
In healthy individuals, the intestinal microbiota cannot access the liver, spleen, or other peripheral tissues. Some pathogenic bacteria can reach these sites, however, and can induce a systemic immune response. How such compartmentalization is achieved is unknown. We identify a gut-vascular barrier (GVB) in mice and humans that controls the translocation of antigens into the blood stream and prohibits entry of the microbiota. Salmonella typhimurium can penetrate the GVB in a manner dependent… CONTINUE READING
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