A growth hormone receptor mutation impairs growth hormone autofeedback signaling in pituitary tumors.

@article{Asa2007AGH,
  title={A growth hormone receptor mutation impairs growth hormone autofeedback signaling in pituitary tumors.},
  author={Sylvia L Asa and Rebecca Digiovanni and Jing Jiang and M. Leanne Ward and Kimberly A Loesch and Shozo Yamada and Toshiaki Sano and Katsuhiko Yoshimoto and Stuart J. Frank and Shereen Ezzat},
  journal={Cancer research},
  year={2007},
  volume={67 15},
  pages={7505-11}
}
Pituitary tumors are a diverse group of neoplasms that are classified based on clinical manifestations, hormone excess, and histomorphologic features. Those that cause growth hormone (GH) excess and acromegaly are subdivided into morphologic variants that have not yet been shown to have pathogenetic significance or predictive value for therapy and outcome. Here, we identify a selective somatic histidine-to-leucine substitution in codon 49 of the extracellular domain of the GH receptor (GHR) in… CONTINUE READING
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Pathology and genetics of tumours of endocrine organs. WHO classification of tumours

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