A growing family of dual specificity phosphatases with low molecular masses.

@article{Aoki2001AGF,
  title={A growing family of dual specificity phosphatases with low molecular masses.},
  author={Naohito Aoki and Kohji Aoyama and Makiko Nagata and Tsukasa Matsuda},
  journal={Journal of biochemistry},
  year={2001},
  volume={130 1},
  pages={133-40}
}
Five putative dual specificity protein phosphatases (DSPs), designated LMW-DSP1, -DSP4, -DSP6, -DSP10, and -DSP11, were cloned with a combination of RT-PCR and cDNA library screening strategies. Sequencing analysis revealed that all lacked the cdc25 homology domain that is conserved in most known DSPs/MAP kinase phosphatases (MKPs). LMW-DSP1 exhibited the highest similarity to plant DSPs. LMW-DSP4 exhibited the highest similarity to human YVH1 and rat GKAP, but its C-terminal region was much… CONTINUE READING