A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: possible immunological state of the intrinsic type.

@article{KabashimaKubo2012AGO,
  title={A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: possible immunological state of the intrinsic type.},
  author={Rieko Kabashima-Kubo and Motonobu Nakamura and Jun-ichi Sakabe and Kazunari Sugita and Ryosuke Hino and Tomoko Mori and Miwa Kobayashi and Toshinori Bito and Kenji Kabashima and Koetsu Ogasawara and Yukiko Nomura and Toshifumi Nomura and Masashi Akiyama and Hiroshi Shimizu and Yoshiki Tokura},
  journal={Journal of dermatological science},
  year={2012},
  volume={67 1},
  pages={37-43}
}
BACKGROUND Atopic dermatitis (AD) can be classified into the major extrinsic type with high serum IgE levels and impaired barrier, and the minor intrinsic type with normal IgE levels and unimpaired barrier. OBJECTIVE To characterize the intrinsic type of Japanese AD patients in the T helper cell polarization in relation to the barrier condition. METHODS Enrolled in this study were 21 AD patients with IgE<200kU/L (IgE-low group; 82.5±59.6kU/L) having unimpaired barrier, and 48 AD patients… CONTINUE READING