A group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility

@article{Zimmerly1995AGI,
  title={A group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility},
  author={Steven Zimmerly and Huatao Guo and Robert Eskest and Jian Yang and Philip S. Perlman and Alan M. Lambowitz},
  journal={Cell},
  year={1995},
  volume={83},
  pages={529-538}
}
The mobility (homing) of the yeast mitochondrial DNA group II intron al2 occurs via target DNA-primed reverse transcription at a double-strand break in the recipient DNA. Here, we show that the site-specific DNA endonuclease that makes the double-strand break is a ribonucleoprotein complex containing the al2-encoded reverse transcriptase protein and excised al2 RNA. Remarkably, the al2 RNA catalyzes cleavage of the sense strand of the recipient DNA, while the al2 protein appears to cleave the… CONTINUE READING

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