A ground state of PPARγ activity and expression is required for appropriate neural differentiation of hESCs.

  title={A ground state of PPARγ activity and expression is required for appropriate neural differentiation of hESCs.},
  author={Marjan Taheri and Ahmad Salamian and Kamran Ghaedi and Maryam Peymani and Tayebeh Izadi and Alireza Nejati and Atefeh Atefi and Marzieh Nematollahi and Fatemeh Ahmadi Ghahrizjani and Maryam Esmaeili and Abbas Kiani Esfahani and Shiva Irani and Hossein Baharvand and Mohammad-Hossein Nasr-Esfahani},
  journal={Pharmacological reports : PR},
  volume={67 6},
BACKGROUND Several evidences indicate stimulation of peroxisome proliferator activated receptor γ (PPARg), promotes neuronal differentiation. This study was conducted to testify the prominence of PPARγ during neural differentiation of human embryonic stem cells (hESCs). METHODS PPARγ expression level was assessed during neural differentiation of hESCs. Meanwhile, the level of endogenous miRNAs, which could be engaged in regulation of PPARγ expression, was measured. Next, natural and synthetic… CONTINUE READING
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