A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cells.

@article{Feng2011AGF,
  title={A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cells.},
  author={Lingyan Feng and Yong Chen and Jinsong Ren and Xiaogang Qu},
  journal={Biomaterials},
  year={2011},
  volume={32 11},
  pages={2930-7}
}
Here we report an electrochemical sensor that can realize label-free cancer cell detection using the first clinical trial II used aptamer AS1411 and functionalized graphene. By taking advantages of AS1411 high binding affinity and specificity to the overexpressed nucleolin on the cancer cell surface, our developed electrochemical aptasensor can distinguish cancer cells and normal ones and detect as low as one thousand cells. With DNA hybridization technique, this E-DNA sensor can be regenerated… CONTINUE READING

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