A granular variant of CD63 is a regulator of repeated human mast cell degranulation.

@article{Schaefer2010AGV,
  title={A granular variant of CD63 is a regulator of repeated human mast cell degranulation.},
  author={Thorsten Schaefer and Philipp M. Starkl and C. Kenneth Allard and Risa M. Wolf and Tam{\'a}s Schweighoffer},
  journal={Allergy},
  year={2010},
  volume={65 10},
  pages={1242-55}
}
BACKGROUND Mast cells are secretory immune cells whose degranulation can provoke acute allergic reactions. It is presently unclear, however, whether an individual mast cell can repeatedly degranulate or turns dysfunctional after a single antigen stimulus. This work thus aims to better define the mast cell life cycle, with particular focus on new target structures for therapeutic or diagnostic approaches in allergy. METHODS Monoclonal antibodies were raised against degranulated cord blood… CONTINUE READING

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