A grading system to evaluate objectively the strength of pre-clinical data of acute neuroprotective therapies for clinical translation in spinal cord injury.

@article{Kwon2011AGS,
  title={A grading system to evaluate objectively the strength of pre-clinical data of acute neuroprotective therapies for clinical translation in spinal cord injury.},
  author={Brian K Kwon and Elena B. Okon and Eve Y. Tsai and Michael S Beattie and J C Bresnahan and David S. K. Magnuson and P. Reier and Dana M McTigue and Phillip G. Popovich and Andrew R. Blight and Martin Oudega and James David Guest and Lynne C. Weaver and Michael G. Fehlings and Wolfram Tetzlaff},
  journal={Journal of neurotrauma},
  year={2011},
  volume={28 8},
  pages={1525-43}
}
The past three decades have seen an explosion of research interest in spinal cord injury (SCI) and the development of hundreds of potential therapies that have demonstrated some promise in pre-clinical experimental animal models. A growing number of these treatments are seeking to be translated into human clinical trials. Conducting such a clinical trial… CONTINUE READING