A gradient model of cardiac pacemaker myocytes.
@article{Lovell2004AGM, title={A gradient model of cardiac pacemaker myocytes.}, author={Nigel Hamilton Lovell and Shaun L. Cloherty and Branko George Celler and Socrates Dokos}, journal={Progress in biophysics and molecular biology}, year={2004}, volume={85 2-3}, pages={ 301-23 } }
Figures and Tables from this paper
34 Citations
A comparison of 1-D models of cardiac pacemaker heterogeneity
- BiologyIEEE Transactions on Biomedical Engineering
- 2006
It is concluded that the gradient model of SAN heterogeneity, in the presence of a uniform conductivity profile, is the most likely model ofSAN organization.
Qualitative Support for the Gradient Model of Cardiac Pacemaker Heterogeneity
- Biology2005 IEEE Engineering in Medicine and Biology 27th Annual Conference
- 2005
Simulation results suggest that the gradient model of SAN heterogeneity, in which cells display a smooth variation in membrane properties from the center to the periphery of the SAN, best reproduces action potential waveshapes.
Computational Model of Rabbit SA Node Pacemaker Activity Probed with Action Potential and Calcium Transient Clamp
- Biology2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- 2007
To better appreciate the contribution of individual ionic currents to pacemaker activity in a computational model of an SA nodal cell, a realistic action potential shape and calcium transient on the model cell is imposed.
Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity
- BiologyComput. Math. Methods Medicine
- 2013
A generic cardiomyocyte ionic model, whose complexity lies between a simple phenomenological formulation and a biophysically detailed ionic membrane current description, is presented and is optimised to accurately reproduce multiple action potential waveforms recorded experimentally from a range of cardiac myocytes.
A generic ionic model of cardiac action potentials
- Biology2010 Annual International Conference of the IEEE Engineering in Medicine and Biology
- 2010
A generic cardiac ionic model employing membrane currents based on two-gate Hodgkin-Huxley kinetics is presented. Its generic nature allows it to accurately reproduce action potential waveforms in…
Tissue-based optimization of a sino-atrial node disc model
- Biology2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- 2011
A cardiac sino-atrial tissue model based on a simplified 2D disc geometry and a generic ionic model is described and optimized to fit intact-tissue microelectrode experimental recordings and offers an improved representation of the electrotonic interactions between heterogenous cell types.
Computer modelling of the sinoatrial node
- BiologyMedical & Biological Engineering & Computing
- 2006
In this review, an overview is given of the progress made in cardiac cell modelling, with particular emphasis on the development of sinoatrial (SA) nodal cell models.
Computer modelling of the sinoatrial node
- BiologyMedical & Biological Engineering & Computing
- 2006
In this review, an overview is given of the progress made in cardiac cell modelling, with particular emphasis on the development of sinoatrial (SA) nodal cell models.
A Parameter Representing Missing Charge Should Be Considered when Calibrating Action Potential Models
- BiologyFrontiers in Physiology
- 2022
The value of making Γ0 explicit in model formulations, as it forces modellers and experimenters to consider the effects of uncertainty and potential discrepancy in initial concentrations upon model predictions, is shown.
Simulation of Cardiac Action Potentials
- Biology
- 2011
The chapter begins with an overview of the cardiac action potential and highlights the Hodgkin and Huxley formalism, and focuses on modeling mutant sodium channels and the ability of modeling to elucidate pharmacodynamic mechanisms of sodium channel drug blockade.
References
SHOWING 1-10 OF 30 REFERENCES
A mathematical model of a rabbit sinoatrial node cell.
- BiologyThe American journal of physiology
- 1994
This model provides acceptable fits to voltage-clamp and action potential data and can be used to seek biophysically based explanations of the electrophysiological activity in the rabbit sinoatrial node cell.
Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell.
- BiologyAmerican journal of physiology. Heart and circulatory physiology
- 2002
An improved mathematical model for a single primary pacemaker cell of the rabbit sinoatrial node that can simulate whole cell voltage-clamp data for I(Ca,L), I(Kr), and I(st) and mimic the effects of channel blockers or Ca(2+) buffers on pacemaker activity more accurately than the previous models is developed.
Ion currents underlying sinoatrial node pacemaker activity: a new single cell mathematical model.
- BiologyJournal of theoretical biology
- 1996
Simulations of spontaneous activity suggest that the dominant mechanism underlying pacemaker depolarisation is the inward background Na+ current, ib,Na, while a closer inspection of the current-voltage characteristics of the model revealed that the "instantaneous" time-independent current was inward for holding potentials in the pacemaker range, which rapidly became outward within 2 ms.
Cell-specific ionic models of cardiac pacemaker activity
- Biology2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- 2001
A generic ionic model of single-cell rabbit sinoatrial node (SAN) electrical activity is developed, employing Markov-state kinetics for membrane ionic currents, allowing the ability to quantitatively investigate the contribution of ion currents underlying pacemaker and action potential activity from any given SAN myocyte recording.
Pacemaker activity of the rabbit sinoatrial node. A comparison of mathematical models.
- BiologyBiophysical journal
- 1991
Mechanisms of Sinoatrial Pacemaker Synchronization: A New Hypothesis
- BiologyCirculation research
- 1987
The hypothesis that sinus node synchronization occurs through a "democratic" process resulting from the phase-dependent interactions of thousands of pacemakers is supported.
Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node.
- BiologyAmerican journal of physiology. Heart and circulatory physiology
- 2000
Simulated action potentials are consistent with those recorded experimentally and have a more negative takeoff potential, faster upstroke, more positive peak value, prominent phase 1 repolarization, greater amplitude, shorter duration, and more negative maximum diastolic potential than the model-generated central action potential.
A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations
- BiologyProceedings of the Royal Society of London. Series B. Biological Sciences
- 1984
DiFrancesco & Noble’s (1984) equations have been modified to apply to the mammalian sino-atrial node and successfully reproduce action potential and pacemaker activity in the node.
Dynamic Interactions and Mutual Synchronization of Sinoatrial Node Pacemaker Cells A Mathematical Model
- BiologyCirculation research
- 1986
It is demonstrated that the mutual entrainment of coupled pacemakers can lead to their coordinated behavior (synchronization), and the overall results may be used to predict higher order interactions of thousands of cells comprising the sinus node.