A gradient model of cardiac pacemaker myocytes.

  title={A gradient model of cardiac pacemaker myocytes.},
  author={Nigel H. Lovell and Shaun L. Cloherty and Branko George Celler and Socrates Dokos},
  journal={Progress in biophysics and molecular biology},
  volume={85 2-3},
We have formulated a spatial-gradient model of action potential heterogeneity within the rabbit sinoatrial node (SAN), based on cell-specific ionic models of electrical activity from its central and peripheral regions. The ionic models are derived from a generic cell model, incorporating five background and exchange currents, and seven time-dependent currents based on three- or four-state Markov schemes. State transition rates are given by non-linear sigmoid functions of membrane potential. By… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 13 extracted citations


Publications referenced by this paper.
Showing 1-10 of 32 references

A curvilinear gradient path method for optimization of biological systems models

  • S. Dokos, N. H. Lovell
  • Proceedings of the Fifth IFAC Symposium on…
  • 2003
Highly Influential
4 Excerpts

Computational approaches to the ionic basis of pacemaker activity–from channel kinetics to the regional differences in rhythm

  • H. Zhang, A. V. Holden, M. R. Boyett
  • Chaos, Solitons and Fractals
  • 2002
3 Excerpts

Similar Papers

Loading similar papers…