A gradient model of cardiac pacemaker myocytes.

@article{Lovell2004AGM,
  title={A gradient model of cardiac pacemaker myocytes.},
  author={Nigel H. Lovell and Shaun L. Cloherty and Branko George Celler and Socrates Dokos},
  journal={Progress in biophysics and molecular biology},
  year={2004},
  volume={85 2-3},
  pages={301-23}
}
We have formulated a spatial-gradient model of action potential heterogeneity within the rabbit sinoatrial node (SAN), based on cell-specific ionic models of electrical activity from its central and peripheral regions. The ionic models are derived from a generic cell model, incorporating five background and exchange currents, and seven time-dependent currents based on three- or four-state Markov schemes. State transition rates are given by non-linear sigmoid functions of membrane potential. By… CONTINUE READING

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