A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging.

@article{Mainero2015AGI,
  title={A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging.},
  author={Caterina Mainero and C{\'e}line Louapre and Sindhuja Tirumalai Govindarajan and Costanza Giann{\`i} and A. Scott Nielsen and Julien Cohen-Adad and Jacob A. Sloane and R. P. Kinkel},
  journal={Brain : a journal of neurology},
  year={2015},
  volume={138 Pt 4},
  pages={932-45}
}
We used a surface-based analysis of T2* relaxation rates at 7 T magnetic resonance imaging, which allows sampling quantitative T2* throughout the cortical width, to map in vivo the spatial distribution of intracortical pathology in multiple sclerosis. Ultra-high resolution quantitative T2* maps were obtained in 10 subjects with clinically isolated syndrome/early multiple sclerosis (≤ 3 years disease duration), 18 subjects with relapsing-remitting multiple sclerosis (≥ 4 years disease duration… CONTINUE READING
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