A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish

@article{Neave1997AGR,
  title={A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish},
  author={Byron Neave and Nigel Holder and Roger Patient},
  journal={Mechanisms of Development},
  year={1997},
  volume={62},
  pages={183-195}
}
The effects of signal perturbation on expression domains of molecular markers for the mesoderm and ectoderm have been analysed across the dorso-ventral axis in zebrafish embryos. Injection of RNA encoding bone morphogenetic protein-4 (BMP-4) ventralised the embryo, expanding the intermediate mesoderm and non-neural ectoderm at the expense of the dorso-anterior mesoderm and neural plate. A dose-dependent response was observed both morphologically and in expression of gta3, MyoD and pax2… CONTINUE READING
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