A golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes

@article{Schmechel2004AGS,
  title={A golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes},
  author={Donald E. Schmechel and Pasko Rakic},
  journal={Anatomy and Embryology},
  year={2004},
  volume={156},
  pages={115-152}
}
SummaryRadial glial cells (epithelial cells of Ramón y Cajal) impregnated by a modified del Rio Hortega rapid Golgi method were studied in the occipital lobes of 38 rhesus monkeys from embryonic day 48 (E48) to birth which occurs at E165 and in 27 postnatal animals to day 365 (P365). Some radial glial cells are already recognized at E48 by their bipolar shape and elongated radial fiber, which terminates with characteristic endfeet on the walls of blood vessels or at the pial surface. At… 
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Radial glial cells become the main progenitor in the developing cerebrum by the start of neurogenesis, as all dividing cells show glial features such as GFAP expression and lack of tight junctions, and data suggest that RGCs retract their apical process during mitosis.
Radial secretory glia conserved in the postnatal vertebrate brain: a study in the rat
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Characteristic features for all subcommissural cells are that they appear very early during ontogeny, are derived from a radial oriented glial cell type, carry at least one kinocilium, possess an original intermediate filament pattern, and release a secretory product.
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It is suggested that multipotential progenitors coexist with restricted neuronal progenitor and RG cells during initial corticogenesis in the human telencephalon and the diversification of cells in human VZ and overlying subventricular zone (SVZ) begins earlier and is more pronounced than in rodents.
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  • Biology, Medicine
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  • 2004
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The (not necessarily) convoluted role of basal radial glia in cortical neurogenesis.
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New information is provided about radial glial cells in common marmosets, a near-lissencephalic primate, and in agouti, aNear-gyrencephalic rodent, that demonstrate that bRG are abundant and proliferate in inner as well as oSVZ, in both species, and that differential regulation of bRG and other progenitor types may enhance the adaptability and diversity of cortical morphogenesis.
Elusive radial glial cells: Historical and evolutionary perspective
TLDR
The multiple functions of radial glial cells and their species‐specific adaptations indicate a pivotal role in evolution, development, and pathology of the cerebral neocortex.
Populations of Radial Glial Cells Respond Differently to Reelin and Neuregulin1 in a Ferret Model of Cortical Dysplasia
TLDR
The lab developed a model of cortical dysplasia in the ferret, resulting in impaired migration of neurons into the cortical plate and disordered radial glia, and tested whether radial glial repair correlated with improved neuronal migration.
Mitosis of radial glial cells in the optic tectum of adult goldfish
  • J. A. Stevenson, M. Yoon
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1981
TLDR
Observations suggest that radial glial cells of the adult goldfish tectum can be induced (presumably by mitogenic effects of regenerating optic nerve fibers) to undergo mitosis.
Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus
TLDR
It is demonstrated that the expression of brain lipid‐binding protein, GLAST, and glial fibrillary acidic protein (GFAP) characterizes immature differentiating cells confined to an astrocytic fate in the early postnatal dentate gyrus.
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