A glycosylated nitric oxide donor, beta-Gal-NONOate, and its site-specific antitumor activity.

@article{Chen2006AGN,
  title={A glycosylated nitric oxide donor, beta-Gal-NONOate, and its site-specific antitumor activity.},
  author={Chang Chen and Yanqiu Shi and Song Li and Qingsheng Qi and Li Gu and Jing Song and Peng George Wang},
  journal={Archiv der Pharmazie},
  year={2006},
  volume={339 7},
  pages={366-71}
}
So far, nitric oxide (NO) donors have been applied to various aspects of antitumor therapy. To selectively sensitize tumor cells and avoid unwanted side effects, we recently synthesized a beta-galactosidase-activatable NO-releasing compound, beta-galactosyl-pyrrolidinyl diazeniumdiolate (beta-Gal-NONOate). In this study, we first verified its superiority over its parent diazeniumdiolate (NONOate) in terms of targeted intracellular NO-releasing and antitumor activity with 9L/LacZ cells (rat… CONTINUE READING

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