A glycolytic enzyme, enolase, is recruited as a cofactor of tRNA targeting toward mitochondria in Saccharomyces cerevisiae.

@article{Entelis2006AGE,
  title={A glycolytic enzyme, enolase, is recruited as a cofactor of tRNA targeting toward mitochondria in Saccharomyces cerevisiae.},
  author={Nina Entelis and Irina Brandina and Piotr Kamenski and I. Krasheninnikov and Robert Pierre Martin and Ivan Tarassov},
  journal={Genes & development},
  year={2006},
  volume={20 12},
  pages={
          1609-20
        }
}
  • Nina Entelis, Irina Brandina, +3 authors Ivan Tarassov
  • Published 2006
  • Biology, Medicine
  • Genes & development
  • In many organisms, mitochondria import nuclear DNA-encoded small RNAs. In yeast Saccharomyces cerevisiae, one out of two cytoplasmic isoacceptor tRNAs(Lys) is partially addressed into the organelle. Mitochondrial targeting of this tRNA was shown to depend on interaction with the precursor of mitochondrial lysyl-tRNA synthetase, preMsk1p. However, preMsk1p alone was unable to direct tRNA targeting, suggesting the existence of additional protein factor(s). Here, we identify the glycolytic enzyme… CONTINUE READING

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