A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins.

Abstract

The complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HPbetaCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS(3))(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins.

DOI: 10.1039/b915839a

Cite this paper

@article{Marques2009AGR, title={A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins.}, author={Joana Isabel Marques and Teresa Margarida Santos and M P M Marques and Susana Santos Braga}, journal={Dalton transactions}, year={2009}, volume={44}, pages={9812-9} }