A glutamic acid residue at position 31 of Ras protein is essential to the signal transduction for neurite outgrowth of PC12 cells and the stimulation of GTPase activity by GAPRas.

Abstract

The roles of residues at positions 23-31 adjacent to the 'effector region' and residues at positions 61-65 in a phosphoryl binding loop of the human c-Ha-ras protein were studied by changing each residue of the normal (Gly-12 type) and oncogenic (Val-12 type) Ras proteins to the corresponding residue of the K-rev-1 protein. Firstly, the signal-transducing… (More)

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@article{Shirouzu1992AGA, title={A glutamic acid residue at position 31 of Ras protein is essential to the signal transduction for neurite outgrowth of PC12 cells and the stimulation of GTPase activity by GAPRas.}, author={Mikako Shirouzu and Junko Fujita-Yoshigaki and Yoko Ito and H. B. Koide and Shintaro Nishimura and Shigeru Yokoyama}, journal={Oncogene}, year={1992}, volume={7 3}, pages={475-80} }