A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis.

@article{Higgins2015AGN,
  title={A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis.},
  author={Gerald A. Higgins and Ari Allyn-Feuer and Edward M. Barbour and Brian D. Athey},
  journal={Pharmacogenomics},
  year={2015},
  volume={16 14},
  pages={
          1547-63
        }
}
AIM A regulatory network in the human brain mediating lithium response in bipolar patients was revealed by analysis of functional SNPs from genome-wide association studies (GWAS) and published gene association studies, followed by epigenome mapping. METHODS An initial set of 23,312 SNPs in linkage disequilibrium with lead SNPs, and sub-threshold GWAS SNPs rescued by pathway analysis, were studied in the same populations. These were assessed using our workflow and annotation by the epigenome… CONTINUE READING
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