A glutamatergic hypothesis of drug dependence: extrapolations from benzodiazepine receptor ligands.

@article{Stephens1995AGH,
  title={A glutamatergic hypothesis of drug dependence: extrapolations from benzodiazepine receptor ligands.},
  author={D. N. Stephens},
  journal={Behavioural pharmacology},
  year={1995},
  volume={6 5 And 6},
  pages={425-446}
}
This article explores some of the data available on processes underlying dependence and withdrawal following chronic treatment with substances acting at GABA(A) receptors. It is argued that adaptations arising from chronic treatment with benzodiazepines (BZs) and ethanol, on the one hand, and inverse agonists at BZ receptors, on the other, cannot be explained by changes primarily in GABAergic systems, and that compensatory changes in glutamatergic transmission account at least partially for… CONTINUE READING
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