A glutamate switch controls voltage-sensitive phosphatase function

@inproceedings{Liu2012AGS,
  title={A glutamate switch controls voltage-sensitive phosphatase function},
  author={Lijun Leo Liu and Susy C Kohout and Qiang Xu and Simone M{\"u}ller and Christopher R. Kimberlin and Ehud Y Isacoff and Daniel L Minor},
  booktitle={Nature Structural &Molecular Biology},
  year={2012}
}
The Ciona intestinalis voltage-sensing phosphatase (Ci-VSP) couples a voltage-sensing domain (VSD) to a lipid phosphatase that is similar to the tumor suppressor PTEN. How the VSD controls enzyme function has been unclear. Here, we present high-resolution crystal structures of the Ci-VSP enzymatic domain that reveal conformational changes in a crucial loop, termed the 'gating loop', that controls access to the active site by a mechanism in which residue Glu411 directly competes with substrate… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 34 references

Electrochemical coupling in the voltage - dependent phosphatase Ci - VSP

S. C. Kohout
Nat . Chem . Biol . • 2010

How membrane proteins sense voltage

Nature Reviews Molecular Cell Biology • 2008

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