A glutamate switch controls voltage-sensitive phosphatase function

  title={A glutamate switch controls voltage-sensitive phosphatase function},
  author={Lijun Leo Liu and Susy C Kohout and Qiang Xu and Simone M{\"u}ller and Christopher R. Kimberlin and Ehud Y Isacoff and Daniel L Minor},
  booktitle={Nature Structural &Molecular Biology},
The Ciona intestinalis voltage-sensing phosphatase (Ci-VSP) couples a voltage-sensing domain (VSD) to a lipid phosphatase that is similar to the tumor suppressor PTEN. How the VSD controls enzyme function has been unclear. Here, we present high-resolution crystal structures of the Ci-VSP enzymatic domain that reveal conformational changes in a crucial loop, termed the 'gating loop', that controls access to the active site by a mechanism in which residue Glu411 directly competes with substrate… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 17 extracted citations

Phosphoinositide 5- and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage dependence.

Proceedings of the National Academy of Sciences of the United States of America • 2016
View 6 Excerpts
Highly Influenced

Functional diversity of voltage‐sensing phosphatases in two urodele amphibians

Physiological reports • 2014
View 11 Excerpts
Highly Influenced

Voltage-Controlled Enzymes: The New Janus Bifrons

Front. Pharmacol. • 2012
View 10 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 34 references

Electrochemical coupling in the voltage - dependent phosphatase Ci - VSP

S. C. Kohout
Nat . Chem . Biol . • 2010

How membrane proteins sense voltage

Nature Reviews Molecular Cell Biology • 2008

Similar Papers

Loading similar papers…