A global view of pleiotropy and phenotypically derived gene function in yeast

  title={A global view of pleiotropy and phenotypically derived gene function in yeast},
  author={Aim{\'e}e Marie Dudley and Daniel Maarten Janse and Amos Tanay and Ron Shamir and George M Church},
  journal={Molecular Systems Biology},
  pages={2005.0001 - 2005.0001}
Pleiotropy, the ability of a single mutant gene to cause multiple mutant phenotypes, is a relatively common but poorly understood phenomenon in biology. Perhaps the greatest challenge in the analysis of pleiotropic genes is determining whether phenotypes associated with a mutation result from the loss of a single function or of multiple functions encoded by the same gene. Here we estimate the degree of pleiotropy in yeast by measuring the phenotypes of 4710 mutants under 21 environmental… CONTINUE READING
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