A global test for groups of genes: testing association with a clinical outcome

  title={A global test for groups of genes: testing association with a clinical outcome},
  author={Jelle J. Goeman and Sara A. van de Geer and Floor de Kort and Hans C. van Houwelingen},
  volume={20 1},
MOTIVATION This paper presents a global test to be used for the analysis of microarray data. Using this test it can be determined whether the global expression pattern of a group of genes is significantly related to some clinical outcome of interest. Groups of genes may be any size from a single gene to all genes on the chip (e.g. known pathways, specific areas of the genome or clusters from a cluster analysis). RESULT The test allows groups of genes of different size to be compared, because… CONTINUE READING
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