A global regulatory mechanism for activating an exon network required for neurogenesis.

@article{Raj2014AGR,
  title={A global regulatory mechanism for activating an exon network required for neurogenesis.},
  author={B. Kranthi Raj and Manuel Irimia and Ulrich Braunschweig and Timothy H Sterne-Weiler and Dave O'Hanlon and Zhen‐Yuan Lin and Ginny I. Chen and Laura E. Easton and Ule Jernej and Anne-Claude Gingras and Eduardo Eyras and Benjamin J. Blencowe},
  journal={Molecular cell},
  year={2014},
  volume={56 1},
  pages={90-103}
}
The vertebrate and neural-specific Ser/Arg (SR)-related protein nSR100/SRRM4 regulates an extensive program of alternative splicing with critical roles in nervous system development. However, the mechanism by which nSR100 controls its target exons is poorly understood. We demonstrate that nSR100-dependent neural exons are associated with a unique configuration of intronic cis-elements that promote rapid switch-like regulation during neurogenesis. A key feature of this configuration is the… CONTINUE READING
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