A global profile of replicative polymerase usage

  title={A global profile of replicative polymerase usage},
  author={Yasukazu Daigaku and Andrea Keszthelyi and Carolin A. M{\"u}ller and Izumi Miyabe and Tony S Brooks and Renata Retkute and Michael Hubank and Conrad A. Nieduszynski and Antony M Carr},
  journal={Nature Structural &Molecular Biology},
Three eukaryotic DNA polymerases are essential for genome replication. Polymerase (Pol) α–primase initiates each synthesis event and is rapidly replaced by processive DNA polymerases: Polɛ replicates the leading strand, whereas Polδ performs lagging-strand synthesis. However, it is not known whether this division of labor is maintained across the whole… CONTINUE READING