A global S. cerevisiae small ubiquitin-related modifier (SUMO) system interactome

@inproceedings{Srikumar2013AGS,
  title={A global S. cerevisiae small ubiquitin-related modifier (SUMO) system interactome},
  author={Tharan Srikumar and Megan C. Lewicki and Brian Raught},
  booktitle={Molecular systems biology},
  year={2013}
}
The small ubiquitin-related modifier (SUMO) system has been implicated in a number of biological functions, yet the individual components of the SUMO machinery involved in each of these activities were largely unknown. Here we report the first global SUMO system interactome. Using affinity purification coupled with mass spectrometry, we identify >450 protein-protein interactions surrounding the SUMO E2, Siz type E3s and SUMO-specific proteases in budding yeast. Exploiting this information-rich… CONTINUE READING

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