A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network

@inproceedings{Lee2012AGD,
  title={A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network},
  author={Seung-Tae Lee and Yuanyuan Xiao and Marcus O Muench and Jianqiao Xiao and Marina E Fomin and John K. Wiencke and Shichun Zheng and Xiaoqin Dou and Adam J de Smith and A P Chokkalingam and Patricia A. Buffler and Xiaomei Ma and Joseph Wiemels},
  booktitle={Nucleic acids research},
  year={2012}
}
The epigenetic changes during B-cell development relevant to both normal function and hematologic malignancy are incompletely understood. We examined DNA methylation and RNA expression status during early B-cell development by sorting multiple replicates of four separate stages of pre-B cells derived from normal human fetal bone marrow and applied high-dimension DNA methylation scanning and expression arrays. Features of promoter and gene body DNA methylation were strongly correlated with RNA… CONTINUE READING