A gliotoxin model of occipital seizures in rats

  title={A gliotoxin model of occipital seizures in rats},
  author={Seyed M. Mirsattari and Bixia Shen and L. Stan Leung and Nagalingam Rajakumar},
PURPOSE Intracortical microinjection of fluorocitrate, a reversible inhibitor of glial tricarboxylic acid (TCA), results in impaired glial metabolism and epileptic seizures. To determine the potential contribution of epileptic activities to the metabolic properties of fluorocitrate, we investigated the seizure-inducing property of fluorocitrate at different doses. METHODS Twenty-seven male Sprague Dawley rats (250-400g) were studied with chronically implanted electrodes and cannulae in the… CONTINUE READING


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