A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells

@article{Lee2003AGA,
  title={A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells},
  author={Youngjoo Lee and YoungRan Jin and Wonchung Lim and SangMi Ji and Seungki Lee},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2003},
  volume={84},
  pages={463-468}
}
We have examined the possibility that a component of Panax ginseng, ginsenoside-Rh1, acts by binding to steroid hormone receptors such as receptors for estrogen, glucocorticoid, androgen, and retinoic acid. Ginsenoside-Rh1 activated the transcription of the estrogen-responsive luciferase reporter gene in MCF-7 breast cancer cells at a concentration of 50 microM. Activation was inhibited by the specific estrogen receptor antagonist ICI 182,780, indicating that the estrogenic effect of… CONTINUE READING
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