A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population

@inproceedings{Liu2012AGV,
  title={A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population},
  author={Yao Liu and Qin Zhang and Chuanli Ren and Yanbing Ding and Guangfu Jin and Zhibin Hu and Yaochu Xu and Hongbing Shen},
  booktitle={Journal of biomedical research},
  year={2012}
}
MET tyrosine kinase and its ligand, hepatocyte growth factor (HGF), play a pivotal role in the activties of tumor cells. A germline missense variant in exon 2 of the MET gene, N375S (rs33917957 A>G), may alter the binding affinity of MET for HGF and thus modify the risk of tumorigenesis. In this study, we performed a case-control study to assess the association between N375S and gastric cancer risk in 1,681 gastric cancer cases and 1,858 cancer-free controls. Logistic regression analysis was… CONTINUE READING

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