A germline transgenic silkworm that secretes recombinant proteins in the sericin layer of cocoon

@article{Tomita2007AGT,
  title={A germline transgenic silkworm that secretes recombinant proteins in the sericin layer of cocoon},
  author={Masahiro Tomita and Rika Hino and Shingo Ogawa and Masashi Iizuka and Takahiro Adachi and Katsuhiko Shimizu and Hisaya Sotoshiro and Katsutoshi Yoshizato},
  journal={Transgenic Research},
  year={2007},
  volume={16},
  pages={449-465}
}
A silk thread of the silkworm, Bombyx mori, is composed of the insoluble inner fibroin and the hydrophilic outer sericin layer, which are synthesized in the posterior and middle silk gland (MSG), respectively. This study aimed to develop a novel sericin 1 gene (ser1) promoter-driven recombinant expression system using transgenic silkworms, in which recombinant proteins are synthesized in MSG and secreted into the sericin layer. To obtain a high level of gene expression, we tested whether a… CONTINUE READING