A germline hMSH2 alteration is unrelated to colonic microsatellite instability in patients with ulcerative colitis.

@article{Noffsinger1999AGH,
  title={A germline hMSH2 alteration is unrelated to colonic microsatellite instability in patients with ulcerative colitis.},
  author={Amy E. Noffsinger and Jenine M. Belli and Franz Fogt and Joachim Fischer and Harvey Goldman and C{\'e}cilia M. Fenoglio-preiser},
  journal={Human pathology},
  year={1999},
  volume={30 1},
  pages={
          8-12
        }
}
Recently, a polymorphism in the hMSH2 DNA mismatch repair gene has been associated with the development of dysplasia in ulcerative colitis (UC) patients. This polymorphism is of interest because DNA mismatch repair defects result in alterations in microsatellite stability. The current study was designed to determine whether this hMSH2 polymorphism associates with the development of microsatellite instability and dysplasia in UC patients. The hMSH2 genotype of 96 UC patients was determined by… CONTINUE READING
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