A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.

@article{Kobayashi2001AGT,
  title={A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.},
  author={Tsuneo Kobayashi and Osamu Minowa and Y. Sugitani and Sinichiro Takai and Hiroaki Mitani and Etsuko Kobayashi and Tetsuo Noda and Okio Hino},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 15},
  pages={8762-7}
}
Tuberous sclerosis (TS) is characterized by the development of hamartomas in various organs and is caused by a germ-line mutation in either TSC1 or TSC2 tumor suppressor genes. From the symptomatic resemblance among TS patients, involvement of TSC1 and TSC2 products in a common pathway has been suggested. Here, to analyze the function of the Tsc1 product, we established a line of Tsc1 (TSC1 homologue) knockout mouse by gene targeting. Heterozygous Tsc1 mutant (Tsc1(+/-)) mice developed renal… CONTINUE READING