A geometric approach for the alignment of liquid chromatography - mass spectrometry data

@article{Lange2007AGA,
  title={A geometric approach for the alignment of liquid chromatography - mass spectrometry data},
  author={Eva Lange and Clemens Gr{\"o}pl and Ole Schulz-Trieglaff and Andreas Leinenbach and Christian G. Huber and Knut Reinert},
  journal={Bioinformatics},
  year={2007},
  volume={23 13},
  pages={i273-81}
}
MOTIVATION Liquid chromatography coupled to mass spectrometry (LC-MS) and combined with tandem mass spectrometry (LC-MS/MS) have become a prominent tool for the analysis of complex proteomic samples. An important step in a typical workflow is the combination of results from multiple LC-MS experiments to improve confidence in the obtained measurements or to compare results from different samples. To do so, a suitable mapping or alignment between the data sets needs to be estimated. The alignment… CONTINUE READING