A genotypic assay for the amplification and sequencing of gag and protease from diverse human immunodeficiency virus type 1 group M subtypes.

@article{Laethem2006AGA,
  title={A genotypic assay for the amplification and sequencing of gag and protease from diverse human immunodeficiency virus type 1 group M subtypes.},
  author={Kristel van Laethem and Yoeri Schrooten and Sarah Dedecker and Lies Van Heeswijck and Koen Deforche and Eric van Wijngaerden and Marc van Ranst and Anne-Mieke Vandamme},
  journal={Journal of virological methods},
  year={2006},
  volume={132 1-2},
  pages={181-6}
}
In human immunodeficiency virus type 1 (HIV-1), an interaction exists between the in vivo evolution of Gag protein and protease to escape from antiretroviral drug selective pressure. Therefore, it was decided to develop a genotypic assay for the amplification and sequencing of HIV-1 gag and protease. As the HIV-1 pandemic is characterised by a large genetic diversity, the assay developed was evaluated on a panel of 28 genetically divergent samples belonging to the following subtypes A1, B, C, D… CONTINUE READING
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