A genotype calling algorithm for affymetrix SNP arrays

  title={A genotype calling algorithm for affymetrix SNP arrays},
  author={Nusrat Rabbee and Terence P. Speed},
  volume={22 1},
MOTIVATION A classification algorithm, based on a multi-chip, multi-SNP approach is proposed for Affymetrix SNP arrays. Current procedures for calling genotypes on SNP arrays process all the features associated with one chip and one SNP at a time. Using a large training sample where the genotype labels are known, we develop a supervised learning algorithm to obtain more accurate classification results on new data. The method we propose, RLMM, is based on a robustly fitted, linear model and uses… CONTINUE READING
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