A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes.

@article{Rowlands2013AGA,
  title={A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes.},
  author={Justin Craig Rowlands and Robert A. Budinsky and B. Bhaskar Gollapudi and Michael B. Black and Russell D. Wolfinger and Daniela Cukovic and Alan A. Dombkowski and Chad M Thompson and Jonathan D Urban and Russell S. Thomas},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2013},
  volume={136 2},
  pages={595-604}
}
Toxic equivalency factors (TEFs) for dioxin-like compounds are largely based on relative potency (REP) values derived from biochemical endpoints such as enzyme activity. As of yet, REPs based on gene expression changes have not been accounted for in the TEF values. In this study, primary rat hepatocytes were treated for 24h with 11 concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF), or 2,3,7,8-tetrachlorodibenzofuran (TCDF) ranging from 0.00001 to… CONTINUE READING