A genomic strategy to elucidate modules of oncogenic pathway signaling networks.

  title={A genomic strategy to elucidate modules of oncogenic pathway signaling networks.},
  author={Jeffrey T. Chang and Carlos M. Carvalho and Seiichi Mori and Andrea H Bild and Michael L. Gatza and Quanli Wang and Joseph E. Lucas and Anil Potti and Phillip G. Febbo and Mike West and J. R. Nevins},
  journal={Molecular cell},
  volume={34 1},
Recent studies have emphasized the importance of pathway-specific interpretations for understanding the functional relevance of gene alterations in human cancers. Although signaling activities are often conceptualized as linear events, in reality, they reflect the activity of complex functional networks assembled from modules that each respond to input signals. To acquire a deeper understanding of this network structure, we developed an approach to deconstruct pathways into modules represented… CONTINUE READING

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BFRM: Bayesian factor regression modelling

  • Q. Wang, C. Carvalho, J. E. Lucas, M. West
  • Bull Intl Soc Bayesian Anal 14, 4–5.
  • 2007
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