A genomic storm in critically injured humans

  title={A genomic storm in critically injured humans},
  author={Wenzhong Xiao and Michael N. Mindrinos and Junhee Seok and Joseph Cuschieri and Alex Gervacio Cuenca and Hong Gao and Douglas L. Hayden and Laura Hennessy and Ernest Eugene Moore and Joseph P. Minei and Paul E. Bankey and Jeffrey R. Johnson and Jason Lee Sperry and Avery B Nathens and Timothy R Billiar and Michael A. West and Bernard H. Brownstein and Philip H. Mason and Henry V Baker and Celeste C. Finnerty and Marc Gerhard Jeschke and Mar{\'i}a Cecilia L{\'o}pez and Matthew Brady Klein and Richard L. Gamelli and Nicole S. Gibran and Brett D. Arnoldo and Weihong Xu and Yuping Zhang and Steven E. Calvano and Grace P. McDonald-Smith and David A. Schoenfeld and John D. Storey and J. Perren Cobb and H. Shaw Warren and Lyle L. Moldawer and David N . Herndon and Stephen F. Lowry and Ronald V. Maier and Ronald W. Davis and Ronald G. Tompkins},
  booktitle={The Journal of experimental medicine},
Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well as in healthy subjects receiving low-dose bacterial endotoxin, and show that these severe stresses produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected "genomic storm." In severe blunt trauma, the early leukocyte genomic response is consistent with… CONTINUE READING
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