A genomic region associated with protection against severe COVID-19 is inherited from Neandertals

@article{Zeberg2021AGR,
  title={A genomic region associated with protection against severe COVID-19 is inherited from Neandertals},
  author={H. Zeberg and S. P{\"a}{\"a}bo},
  journal={Proceedings of the National Academy of Sciences},
  year={2021},
  volume={118}
}
Significance We show that a haplotype on chromosome 12, which is associated with a ∼22% reduction in relative risk of becoming severely ill with COVID-19 when infected by SARS-CoV-2, is inherited from Neandertals. This haplotype is present at substantial frequencies in all regions of the world outside Africa. The genomic region where this haplotype occurs encodes proteins that are important during infections with RNA viruses. It was recently shown that the major genetic risk factor associated… Expand
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