A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.

@article{Holden2013AGP,
  title={A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.},
  author={Matthew T. G. Holden and Li Yang Hsu and Kevin Kurt and Lucy Anne Weinert and Alison E. Mather and Simon R. Harris and Birgit Strommenger and Franziska Layer and Wolfgang Witte and Herm{\'i}nia de Lencastre and Robert L Skov and Henrik Westh and Helena Zemlickova and Geoffrey Wallace Coombs and Angela M. Kearns and Robert R. Hill and Jonathan D. Edgeworth and Ian Malcolm Gould and Vanya A. Gant and Jonathan Cooke and Giles F. S. Edwards and Paul R. McAdam and Kate E. Templeton and Angela McCann and Zhemin Zhou and Santiago Castillo-Ram{\'i}rez and Edward J Feil and Lyndsey O. Hudson and Mark C. Enright and François Balloux and David M. Aanensen and Brian G. Spratt and J Ross Fitzgerald and Julian 5 Parkhill and Mark Achtman and Stephen D. Bentley and Ulrich Nuebel},
  journal={Genome research},
  year={2013},
  volume={23 4},
  pages={653-64}
}
The widespread use of antibiotics in association with high-density clinical care has driven the emergence of drug-resistant bacteria that are adapted to thrive in hospitalized patients. Of particular concern are globally disseminated methicillin-resistant Staphylococcus aureus (MRSA) clones that cause outbreaks and epidemics associated with health care. The most rapidly spreading and tenacious health-care-associated clone in Europe currently is EMRSA-15, which was first detected in the UK in… CONTINUE READING
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