A genomic code for nucleosome positioning

@article{Segal2006AGC,
  title={A genomic code for nucleosome positioning},
  author={E. Segal and Yvonne N Fondufe-Mittendorf and L. Chen and A. Th{\aa}str{\"o}m and Yair Field and Irene K. Moore and J. Wang and J. Widom},
  journal={Nature},
  year={2006},
  volume={442},
  pages={772-778}
}
Eukaryotic genomes are packaged into nucleosome particles that occlude the DNA from interacting with most DNA binding proteins. Nucleosomes have higher affinity for particular DNA sequences, reflecting the ability of the sequence to bend sharply, as required by the nucleosome structure. However, it is not known whether these sequence preferences have a significant influence on nucleosome position in vivo, and thus regulate the access of other proteins to DNA. Here we isolated nucleosome-bound… Expand
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