A genomic classifier improves prediction of metastatic disease within 5 years after surgery in node-negative high-risk prostate cancer patients managed by radical prostatectomy without adjuvant therapy.

@article{Klein2015AGC,
  title={A genomic classifier improves prediction of metastatic disease within 5 years after surgery in node-negative high-risk prostate cancer patients managed by radical prostatectomy without adjuvant therapy.},
  author={Eric A Klein and Kasra Yousefi and Zaid Haddad and Voleak Choeurng and Christine Buerki and Andrew J. Stephenson and Jianbo Li and Michael W. Kattan and Cristina Magi-Galluzzi and Elai Davicioni},
  journal={European urology},
  year={2015},
  volume={67 4},
  pages={778-86}
}
BACKGROUND Surgery is a standard first-line therapy for men with intermediate- or high-risk prostate cancer. Clinical factors such as tumor grade, stage, and prostate-specific antigen (PSA) are currently used to identify those who are at risk of recurrence and who may benefit from adjuvant therapy, but novel biomarkers that improve risk stratification and that distinguish local from systemic recurrence are needed. OBJECTIVE To determine whether adding the Decipher genomic classifier, a… CONTINUE READING

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