A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)γa as a pancreatic beta cell-specific biomarker

@article{Flamez2010AGA,
  title={A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)γa as a pancreatic beta cell-specific biomarker},
  author={Daisy Flamez and Isabelle Roland and A. Berton and Burak Kutlu and Denis Dufrane and Marjolein Beckers and Erwin de Waele and Ilse Rooman and Luc Bouwens and Anne Clark and Max Lonneux and J. F. Jamar and Serge Goldman and Daniel Mar{\'e}chal and Nathan Goodman and Pierre Rene Gianello and Christophe Van Huffel and Isabelle Salmon and Decio L. Eizirik},
  journal={Diabetologia},
  year={2010},
  volume={53},
  pages={1372-1383}
}
Non-invasive imaging of the pancreatic beta cell mass (BCM) requires the identification of novel and specific beta cell biomarkers. We have developed a systems biology approach to the identification of promising beta cell markers. We followed a functional genomics strategy based on massive parallel signal sequencing (MPSS) and microarray data obtained in human islets, purified primary rat beta cells, non-beta cells and INS-1E cells to identify promising beta cell markers. Candidate biomarkers… CONTINUE READING
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Streptozotocininduced diabetes in large animals (pigs/primates): role of GLUT2 transporter and beta-cell plasticity

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