A genomic analysis of subclinical hypothyroidism in hippocampus and neocortex of the developing rat brain.

@article{Royland2008AGA,
  title={A genomic analysis of subclinical hypothyroidism in hippocampus and neocortex of the developing rat brain.},
  author={Joyce E. Royland and Jack S. Parker and Mary Elizabeth Gilbert},
  journal={Journal of neuroendocrinology},
  year={2008},
  volume={20 12},
  pages={
          1319-38
        }
}
Hypothyroidism during pregnancy and the early postnatal period has severe neurological consequences for the developing offspring. The impact of milder degrees of perturbation of the thyroid axis as encompassed in conditions of subclinical hypothyroidism and hypothyroxinemia, however, has not been established. The present investigation examined the effects of graded levels of hypothyroidism, from subclinical to severe, on global gene expression in the developing rodent brain. Thyroid hormone… CONTINUE READING

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