A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans.

@article{Puppala2006AGS,
  title={A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans.},
  author={Sobha Puppala and Gerald D. Dodd and Sharon Fowler and Rector Arya and Jennifer M Schneider and Vidya S. Farook and Richard P. Granato and Thomas D. Dyer and Laura Almasy and Christopher P. Jenkinson and Andrew K Diehl and Michael P. Stern and John Blangero and Ravindranath Duggirala},
  journal={American journal of human genetics},
  year={2006},
  volume={78 3},
  pages={377-92}
}
Gallbladder disease (GBD) is one of the major digestive diseases. Its risk factors include age, sex, obesity, type 2 diabetes, and metabolic syndrome (MS). The prevalence of GBD is high in minority populations, such as Native and Mexican Americans. Ethnic differences, familial aggregation of GBD, and the identification of susceptibility loci for gallstone disease by use of animal models suggest genetic influences on GBD. However, the major susceptibility loci for GBD in human populations have… CONTINUE READING

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