A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project.

@article{Souto2005AGE,
  title={A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project.},
  author={Juan Carlos Souto and Francisco Blanco-Vaca and Jos{\'e} Manuel Soria and Alfonso Buil and Laura Almasy and Jordi Ord{\'o}{\~n}ez-Llanos and Jes{\'u}s Ma Mart{\'i}n-Campos and Mark Lathrop and William J. H. Stone and John Blangero and J. Fontcuberta},
  journal={American journal of human genetics},
  year={2005},
  volume={76 6},
  pages={925-33}
}
Homocysteine (Hcy) plasma level is an independent risk marker for venous thrombosis, myocardial infarction, stroke, congestive heart failure, osteoporotic fractures, and Alzheimer disease. Hcy levels are determined by the interaction of genetic and environmental factors. The genetic basis is still poorly understood, since only the MTHFR 677 C-->T polymorphism has been consistently associated with plasma Hcy levels. We conducted a genomewide linkage scan for genes affecting variation in plasma… CONTINUE READING