A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.

@article{Zhang2010AGR,
  title={A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.},
  author={Sheng Zhang and Richard Binari and Rui Zhou and Norbert Perrimon},
  journal={Genetics},
  year={2010},
  volume={184 4},
  pages={1165-79}
}
Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs). Understanding their formation and regulation will help clarify their controversial roles in disease pathogenesis. To date, there have been few systematic studies of aggregates formation in Drosophila, a model organism that has been applied extensively in modeling NDs and screening for toxicity modifiers. We generated transgenic fly lines that express enhanced-GFP-tagged mutant Huntingtin (Htt… CONTINUE READING

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