A genome-wide study on the perception of the odorants androstenone and galaxolide.

  title={A genome-wide study on the perception of the odorants androstenone and galaxolide.},
  author={Antti Knaapila and Gu Zhu and Sarah E. Medland and Charles J. Wysocki and Grant W. Montgomery and Nicholas G. Martin and Margaret J. Wright and Danielle R Reed},
  journal={Chemical senses},
  volume={37 6},
Twin pairs and their siblings rated the intensity of the odorants amyl acetate, androstenone, eugenol, Galaxolide, mercaptans, and rose (N = 1573). Heritability was established for ratings of androstenone (h (2) = 0.30) and Galaxolide (h(2) = 0.34) but not for the other odorants. Genome-wide association analysis using 2.3 million single nucleotide polymorphisms indicated that the most significant association was between androstenone and a region without known olfactory receptor genes… CONTINUE READING
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