A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells

@article{Williams2008AGS,
  title={A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells},
  author={Cecilia Williams and Karin Edvardsson and Sebastian A Lewandowski and Anders M. Str{\"o}m and J. {\AA}. Gustafsson},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={1019-1032}
}
Transcriptional effects of estrogen result from its activation of two estrogen receptor (ER) isoforms; ERα that drives proliferation and ERβ that is antiproliferative. Expression of ERβ in xenograft tumors from the T47D breast cancer cell line reduces tumor growth and angiogenesis. If ERβ can halt tumor growth, its introduction into cancers may be a novel therapeutic approach to the treatment of estrogen-responsive cancers. To assess the complete impact of ERβ on transcription, we have made a… CONTINUE READING
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